The single-center, partially blinded, randomized trial involved 150 overweight and obese ambulatory patientswith a BMI of 32.8 kg/m.2 All patients had symptomatic atrial fibrillation and half the patients were on at least one anti-arrhythmic medication. Patients were randomized in a 1:1 ratio to weight management (intervention) or general lifestyle advice (control) and were followed for a median of 15 months. The weight-loss intervention included a very low calorie diet, meal replacements, a written exercise plan, behavioral modification and in-person clinic visits every three months. Routine care consisted of written and verbal advice on nutrition and exercise. Controls were prescribed fish oil (3 g/day), unless they were taking dual antiplatelet agents or oral anticoagulants. In addition to more weight loss, the intervention group also experienced significantly greater reductions in atrial fibrillation symptom burden scores, symptom severity scores, number of episodes, and cumulative duration, compared with the control group, as follows: Symptom severity scores in the intervention group declined 8.4 points compared with 1.7 points among controls (P<0.001) The average number of atrial fibrillation episodes declined an average of 2.5 events in the intervention group compared with no change in controls (P=0.01) garcinia cambogia side effects Cumulative atrial fibrillation duration decreased 692 minutes in the intervention group compared with 419 minutes among controls (P=0.002). In both the intervention and control groups, there was a reduction in interventricular septal thickness (1.1 mm vs.
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Weight Loss Cuts AFib Events
There was a reduction in interventricular septal thickness of 1.1 mm in the intervention group and 0.6 mm in the control group (P=0.02). Finally, left atrial area was reduced 3.5 cm2 in the intervention group and reduced 1.9 cm2 among controls (P=0.02). The researchers said that “the lifestyle and comprehensive metabolic risk factor management program was feasible to deliver, effective, associated with a limited risk of serious adverse events, and resulted in a substantial reduction in the symptom burden and symptom severity of atrial fibrillation.” Study limitations included data from a single center among mostly white male patients. Also, at 150 patients, the study did not achieve the desired sample size.
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To Ensure Weight Reduction, Appropriate Consumption Of Calories Is Needed
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